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Suffix · forms nouns

-ase

Biochemical suffix naming enzymes: lipase = the enzyme that breaks down fats.

In Spanish: -asaScientific

Written by Bryan López, English teacher · Updated June 2026

What this suffix does

The suffix -ase is the international standard for naming enzymes in biochemistry. An enzyme is a protein that catalyses (speeds up) a specific chemical reaction in the body. The first part of the name identifies the substrate (what the enzyme breaks down) or the type of reaction it catalyses. From "lip-" (fat) comes "lipase" (breaks down fats); from "amyl-" (starch) comes "amylase" (breaks down starch); from "prot-" (protein) comes "protease" (breaks down proteins). Spanish: lipase → lipasa, amylase → amilasa, protease → proteasa.

The most important enzymes in medicine and daily life

amylase = breaks down starch (in saliva and pancreas) lipase = breaks down fats (pancreas) protease = breaks down proteins (stomach and pancreas) lactase = breaks down lactose (milk sugar) in the small intestine sucrase = breaks down sucrose (table sugar) DNase = breaks down DNA RNase = breaks down RNA kinase = transfers phosphate groups (key in cell signalling) laccase = oxidises compounds (used in industry) cellulase = breaks down cellulose (plant cell walls)

Lactase: the enzyme most relevant to daily life

"Lactase" is the enzyme that breaks down lactose (milk sugar). "Lactose intolerance" occurs when the body produces too little lactase after infancy — extremely common in Latin American, Asian and African populations. Products like "Lactaid" contain artificial lactase: you take them before eating dairy so the enzyme does the work the body cannot do. Amylase is also easy to experience: chew plain bread for 30 seconds. It starts to taste slightly sweet — your salivary amylase is already breaking the starch into sugar.

How it is formed

Substrate (what is broken down) or reaction type + ase.

  • substrate + ase (enzyme that breaks it down)amyl (starch) = amylase · lip (fat) = lipase · lact (lactose) = lactase · sucr (sucrose) = sucrase
  • biological molecule + aseprot (protein) = protease · DNA = DNase · RNA = RNase · cellulose = cellulase
  • reaction type + asehydro (hydrolysis) = hydrolase · kin (phosphate transfer) = kinase · ox (oxidise) = oxidase · ly (cleavage) = lyase

The -ase suffix was formally adopted by the International Union of Biochemistry in 1961 to standardise enzyme naming. Before that, enzymes had irregular names (e.g. "ptyalin" = now "salivary amylase"). Today every new enzyme gets an -ase name.

How it is pronounced

-ase/eɪz/ · rhymes with 'maze'

Tap the button to hear how the ending sounds. Each word in the table has its own audio.

Examples

Base word
With -ase
In a phrase
  • amyl (starch)amylaseAmylase in your saliva starts breaking down carbohydrates before you even swallow.
  • lip (fat)lipaseThe pancreas produces lipase to help the body digest fats from food.
  • prot (protein)proteaseDoctors prescribed a protease inhibitor to slow the virus from replicating further.
  • lact (lactose)lactasePeople who lack lactase often experience stomach pain after drinking regular milk.
  • sucr (sucrose)sucraseSucrase is the enzyme responsible for converting table sugar into usable energy.
  • DNADNaseThe lab sample was treated with DNase to remove any contaminating genetic material.
  • kin (phosphate)kinaseResearchers found that blocking this kinase reduced the growth of cancer cells significantly.
  • ox (oxidise)oxidaseCytochrome oxidase plays a key role in how cells produce energy from oxygen.
  • cellulosecellulaseFungi release cellulase into the soil to break down tough plant material around them.
  • hydro (water)hydrolaseA hydrolase is any enzyme that uses water molecules to split chemical bonds apart.

Common mistakes

confusing -ase and -ose
-ase = enzyme; -ose = sugar

Two biochemical suffixes that look similar: lactase (enzyme that breaks down lactose). lactose (the sugar itself). -ase = enzyme; -ose = sugar or carbohydrate. glucOSE (sugar) vs glucosidASE (enzyme that breaks it).

amilase (Spanish spelling)
amylase (with y)

"amylase" (not "amilase"). In English, starch is "amyl-" (with y from Greek). The ending is always -ase: amylase, lipase, lactase.

all enzymes are dangerous or artificial
enzymes are natural proteins present in all living organisms

Enzymes are natural proteins the body constantly produces: amylase in saliva, lipase in the pancreas, lactase in the intestine. Only in cases of intolerance or disease are external enzymes used.

A trick to remember it

-ase = enzyme (protein that catalyses a reaction). The first part names the substrate: amyl- (starch), lip- (fat), lact- (lactose), prot- (protein). Key distinction: -ase (enzyme) vs -ose (sugar): lactASE breaks down lactOSE.

Practise what you learned

Exercise 1 · Form the word

Enzyme that breaks down fats: lip___

Hint: lip + ase = ?

Exercise 2 · Pick the right one

What is the difference between "lactase" and "lactose"?

Exercise 3 · Pick the right one

"Lactose intolerance" occurs because...

Frequently asked questions

What does the suffix -ase mean in English?

The suffix -ase biochemical suffix naming enzymes: lipase = the enzyme that breaks down fats. In Spanish it usually maps to -asa.

How do you pronounce -ase?

The ending -ase is pronounced /eɪz/ · rhymes with 'maze'. For example, "amylase".

Can you give an example of a word with -ase?

"amyl (starch)" becomes "amylase". It is a typical example of the -ase suffix.

Other useful suffixes

  • -gen / -genesis

    From Greek "genein" (to produce, to originate): names what produces something or the origin of a process. Oxygen, pathogen.

  • -lysis

    From Greek "lysis" (loosening, dissolving): indicates decomposition, separation or dissolution. Analysis, dialysis.

  • -ology / -logy

    Names a science or field of study: bio + ology = biology.

Learn every English suffix

-tion, -ness, -ful, -ly, -able... every ending you need to understand thousands of words at once.

View all suffixes
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